Winbinder:
“WinBinder is a new open source extension for PHP, the script programming language. It allows PHP programmers to easily build native Windows applications.”

Check out these posts too:

  1. Windows XP Replacements For Vista Applications
  2. The Open Source Web Design Toolbox: 100 Tools, Resources, and Template Sources
  3. Make applications run on Windows startup
  4. Open Source is a valuable resource
  5. A Short Guide To Open-Source And Similar Licenses
  6. Year in Review: Open Source
  7. Just may be the coolest Firefox extension yet.